Twenty-year-old Pablo Maffeo is now the only recognised right-back at City as the club prepare to fly to the United States for pre-season training on Monday.
City and Spurs have reportedly been locked in negotiations over the defender for weeks, with Guardiola's side originally reluctant to offer more than £40m.
As first revealed by Telegraph Sport on Thursday, City have agreed to pay £50m for Walker, plus add-ons that could see the final fee reach £53m, to take the right-back to Manchester.
Furthermore, by promoting Trippier to first-choice, Pochettino would also make room in the squad for the highly promising Kyle Walker-Peters who could act as his understudy.
Capped 27 by England, Walker has made 183 appearances in all competitions for Spurs and was included in the PFA Team of the Year this past April with Spurs finishing runners-up in the league behind Chelsea.
It would be a challenge to find a player who fits the profile of player Spurs would like to sign more.