"We are sixth, Crystal Palace are safe, it doesn't matter", Mourinho said.
"I'm looking at them and analyse where we can win something, win some details, but, on the other hand, I always look at my team, our strengths and how we can beat opponents".
But the manager insists the injured quartet will all travel to Stockholm with the rest of the squad as he hailed United's team spirit.
Jose Mourinho has revealed Timothy Fosu-Mensah could represent a surprise "new option" as he contemplates his team selection for Wednesday's Europa League final against Ajax. "Strong guy, strong mentality". "He's learning how to live after his father passed away, but he is strong".
Mitchell, Harrop, Willock and Dearnley would all be making their United debuts if they play any part against Palace.
Belgium worldwide Marouane Fellaini is a doubt with a hamstring injury while Chris Smalling is set to be rested for the clash with Ajax.
"Imagine now we have Zlatan, Rojo, Shaw, Young, we are not speaking about playing so many kids [against Palace]".
Mourinho dismissed injury concerns surrounding Maroune Fellaini and Juan Mata, despite the former having a "a bad feeling in the hamstring".
"We needed to be clinical perhaps, but we played good football and had chances to win the game".
Ryan Giggs, Paul Scholes and Phil Neville all received the same accolade in the early 1990s and, in recent years, the likes of Axel Tuanzebe and Marcus Rashford have been honoured.
"I hope the fans at Old Trafford support the team, they forgive some naivety, they forgive some lack of confidence and I hope Big Sam shows he's a good friend and he goes slow". They trained with me manytimes.
"The only positive is to save my players to give them better conditions for Wednesday", Mourinho said.
United will go through the motions at Old Trafford on Sunday as the Premier League comes to a meek conclusion, just days before their make-or-break Europa League final against Ajax.
When questioned that if he had appealed directly to the EPL to reschedule the match for Saturday Mourinho said: "When I know a battle is lost I don't fight a battle".