However, a shocking statistic shows that the Manchester club have not recorded a single victory at Anfield in an astonishing 14 years, having lost 15 of their last 20 encounters against the Merseysiders, with their last win coming way back in May 2003.
Jurgen Klopp's men will, however, have to do it without talisman Philippe Coutinho, who completed his proposed move to Barcelona last the weekend, leaving the Reds with a gaping hole where their star forward used to be. Click the right arrow, above, to find out...
Daniel Sturridge (muscle) is a doubt ahead of the game and Jordan Henderson (hamstring) has yet to train.
While City have been irresistible at times this season, this is a strong Liverpool side - strengthened by the addition of Virgil van Dijk in defence.
Pep Guardiola's side are unbeaten in their last 30 fixtures in the Premier League, but that is not to say that a Liverpool side minus their former star man can not end their hopes of being forever known as City's invincibles.
No opposing manager has beaten Pep Guardiola more often than Jurgen Klopp in all competitions (4, level with Jose Mourinho). Liverpool holds a super slight edge at 6-5-7 in its last 19 matches against Manchester City.
Chelsea take on Leicester in a clash of the past two winners of the Premier League, Spurs host Everton, second-placed Manchester United play Stoke and Arsenal, in sixth spot, travel to Bournemouth. Certainly when you look at the teams they compete with on a week to week basis, it's a competitive league.
"You can see yourself that the atmosphere at every home game is fantastic". Any result is possible when Liverpool take to the pitch but if they turn it on this weekend, expect them to inflict City's first domestic setback of the campaign.
"I think in two, three weeks hopefully for the Champions League game against Basel he could be fit".