After these deals, the Bills now own two picks in each of the first, second and third rounds of 2018, a draft that is expected to be rich in quarterback talent.
At least the Bills have a few more draft picks to look forward to - results pending.
Matthews, like Watkins, is eligible for unrestricted free agency after this year. He had foot surgery in the spring, missed half the year, caught for 28 passes for 430 yards in eight games, then had foot surgery again in January. Will he be able to play for the entire season during the appeals process, much like Tom Brady did before his 2016 suspension for Deflategate? The deep ball plays that Watkins once possessed will move to the rookie Zay Jones and the consistent hands of Boldin will be used on the other side of the field when lining up in 3-wideout sets.
Watkins, in three seasons, has caught 153 passes for 2,459 yards and 17 touchdowns.
Some would say the writing was on the wall for Watkins when the Bills declined to exercise the fifth-year option on his contract.
Darby, 23, was a second-round pick of Buffalo in 2015 out of Florida State and represents an immediate upgrade for an Eagles CB depth chart.
It might not be too surprising to see the Bills go with a shorter and quicker passing game in 2017, given their personnel.
The Darby-for-Gaines trade appears to represent an even duller player swap, as each will be competing for a starting job with his new team. It's possible that Seymour competes with recent acquisition E.J. Gaines for the outside cornerback job opposite rookie Tre'Davious White or defeats Leonard Johnson for the slot cornerback job, but Buffalo's top three cornerbacks may be completely different this season.
Los Angeles clearly values Watkins more than the Bills have under their new regime led by coach Sean McDermott. For the past three years, the bounty the Bills gave up in order to select him has been an albatross around his neck, made worse by the fact that Odell Beckham, Jr., was available at the spot where Buffalo was originally supposed to pick.
In the final year of his rookie deal, Watkins could have left the Bills with just a third-round comp pick at the most - or he could have had a good season and the Bills could have franchised or re-signed potentially one of the league's most talented receivers. Giving two first-round picks for Watkins in the 2014 draft was a fatal move by the former GM, an ill-advised reach that followed him for the rest of his tenure.