Rudolph, NFLDraftScout.com's top-rated senior quarterback, was replaced by backup quarterback Taylor Cornelius after Oklahoma State's first drive of the second half.
Before the first quarter was up, Rudolph already threw two touchdowns and the Cowboys led by 21 points.
But what Rudolph did to the Panthers on their home field on Saturday was on another level.
Rudolph, who played only one series in the second half, finished 23-of-32 for 497 yards. His final throw of the day was actually an interception on a deep ball to the end zone with 10:49 left in the quarter - ending a streak of 216 consecutive passes without a pick dating from last season, according to the Associated Press. Washington's 29 receiving touchdowns are the most among active players in the FBS.
But that was essentially the only blemish on Rudolph's afternoon.
"Mason is a workaholic". "And he backs it up". Marcell Ateman (109) and Dillon Stoner (100) also reached the 100-yard receiving mark, the first time in 12 years a team has had four 100-yard receivers in a game.
While Rudolph's eye-popping statistics will earn him plenty of media attention, the scouts attending this game - like Minnesota Vikings general manager Rick Spielman - were likely more impressed with his noticeably improved distribution of the ball and overall awareness of the defense.
Pitt (1-2) simply couldn't keep up. Pitt's offensive line has struggled protecting the quarterback, allowing eight sacks in two games. Do the math: In six quarters against the Panthers, Rudolph passed for 963 yards and seven touchdowns. Browne is averaging just 7.72 yards per completion through two weeks by relying heavily on quick passes and shovel passes.
The Cowboys reached the end zone on each of their first seven possessions, including a pair of touchdown runs by Justice Hill.
OSU moved 54 yards for its fourth touchdown after holding Pittsburgh on fourth down.
- They went 9-for-9 on third downs, with Rudolph completing five passes for conversions.
So much for that first big test. Ateman easily spun off the cornerback trying to cover him and raced 69 yards for the Cowboys' third touchdown of the first quarter.