She reportedly told congressional colleagues last fall that she planned to make the bid after Flake announced in October that he wouldn't run for re-election.
"That's why I told Washington Republicans to grow a pair of ovaries and get the job done", she added. Kelli Ward and notorious former Maricopa County, Ariz.
Later today, McSally, a retired Air Force colonel and the first female fighter pilot to fly a combat mission, plans to fly herself across Arizona in a World War II fighter plane to announce her candidacy in Tucson, Phoenix and Prescott.
"I speak a little salty behind closed doors at times as well, so I'm not going to throw the first stone on using any language", McSally said at a rally in Tucson, Arizona, NBC affiliate Turn To 10 reported.
Republicans lost a Senate seat last month to Democrats in Alabama after Trump and other Washington Republicans in the state's GOP primary backed conservative firebrand Roy Moore over the more moderate Luther Strange.
The candidates will all be vying for the support of President Donald Trump, despite his low approval ratings, and McSally kickstarted her efforts to win his endorsement in her video by including a clip of the president saying, "my friend Martha McSally, she is the real deal. she is tough".
"Like our president, I'm exhausted of PC politicians and their BS excuses", McSally said in her hard-hitting announcement video, released Friday, that also highlighted her career as an Air Force fighter pilot and her eight-year fight to end a military policy requiring female soldiers in certain Muslim-majority countries to wear robes over their military uniforms. Arpaio, 85, served 24 years as sheriff before he was ousted in 2016 by Democrat Paul Penzone.
She also addressed President Trump's comment on Thursday in which he criticized protections for immigrants from "s--hole" countries, a reference to Africa, Haiti and El Salvador. Both Arpaio and Ward are considered border-security hardliners.
McSally is expected to formally announce her campaign Friday morning in a tour across the state, but her campaign tipped its hand by releasing a video hours before.
And the two-term congresswoman is already showing she's got more, er, goods than the hand-wringing anti-Trump RINO now occupying the seat ever dreamed of having. Dems demand Tillerson end State hiring freeze, consult with Congress MORE (R-Ariz.) and had been working to fashion herself the choice for Arizona's more conservative voters in this election.
Arizona congresswoman Martha McSally is launching her bid for the U.S. Senate on Friday. "We won't play politics w/America's safety & military funding".
She co-sponsored an immigration plan considered a conservative wish list of sorts released by House conservatives this week that would reduce legal immigration levels by 25 percent, block federal grants to sanctuary cities and restrict the number of relatives that immigrants already in the US can bring here.
"Currently, Democrats are duking it out in a five-way primary for this Republican-leaning seat".
And though Senate Majority Leader Mitch McConnell - the epitome of the Republican establishment who is hated by some on the far right - has called her one of his top recruits this election cycle, McSally gives D.C. Republicans a rhetorical pounding in the video.