Man United may face Champions League fixture reversal, say UEFA

However, Tottenham were outclassed by Real Madrid at the Bernabeu (4-0) in the first-leg of the quarter-finals, then lost 1-0 back in London.

The four Premier League clubs will be accompanied by FC Barcelona, FC Porto, Juventus and AFC Ajax.

"I would do two matches with English teams, which would mean two in the semi-finals".

But ex-Liverpool man Dossena feels it would be beneficial for Juventus if they can avoid Manchester City in the quarter-finals despite their lack of Champions League pedigree and history.

However, Mourinho, who was sacked by United at the end of previous year, is hoping the Premier League sides are drawn against each other to guarantee two of them reach the final four.

Southgate's squad for this month's European Championship qualifiers has 13 players from the four clubs, including Spurs striker Harry Kane, Liverpool captain Jordan Henderson and City winger Raheem Sterling.

Jose Mourinho wants Manchester United to get Manchester City in the Champions League quarterfinals.

Dutch giants Ajax, however, hold the mantle for the best upset in the competition so far after their two-legged match against reigning champions Real Madrid.

United produced a stunning comeback against Paris Saint-Germain to qualify, while Tottenham beat Borussia Dortmund home and away to secure their place in the draw.

Elsewhere, he said a meeting between the unfancied pair of Porto and Ajax would be a welcome story for the clubs and their respective countries as one of them would at least be guaranteed a semi-final spot.

Not since 2008/09 has the Premier League, or any other league, enjoyed such a privileged position in Europe's premier club competition. Nine years later the Red Devils again booted out an Italian side, this time Roma, which was followed by a narrow 1-0 aggregate success over Barcelona - thanks to Paul Scholes - and a dramatic penalty shoot-out triumph against Chelsea in the Final.

Barcelona, however, beat Juventus in the Champions League final in 2014/15, winning 3-1 in Berlin, with goals from Ivan Rakitic, Luis Suarez and Neymar.

Vanessa Coleman