But Williams was surprisingly beaten by Roberta Vinci in the U.S. Open semifinals last September, by Angelique Kerber in the Australian Open final this January, and by Garbine Muguruza in the French Open final last month.
But Kerber, who overcame Serena's sister Venus 6-4 6-4 in Thursday's semi, is hoping to follow in her compatriot's footsteps by becoming the first German woman to win at the All England Club since 1996.
Champion in 2002, 2003, 2009, 2010, 2012 and 2015, Williams will be contesting her 28th grand slam final in total - and ninth at the All England Club - and is an overwhelming favourite.
Serena's comprehensive victory over Vesnina was the most one-sided women's semi-final at the All England since Graf thrashed Pam Shriver 6-0 6-2 in 1997.
The American fired 11 aces, 28 winners and committed just seven unforced errors, breaking serve five times to reach her 28th Grand Slam final.
Angelique Kerber has warned Serena Williams she's more unsafe on grass, ahead of Saturday's Australian Open final rematch in the Wimbledon decider.
Serena and Venus Williams played both singles and doubles at Wimbledon on Thursday.
The Williams first serve, such a weapon on her best days, lacked its usual power and Kerber took advantage, holding the break all the way through and then clinching victory with a brilliant forehand pass on the run. "We've had tough matches before and I knew she could bring it to me on this surface", said Williams, who has now defeated the Russian five times in five meetings. When I go into a final I need to be fearless like she was. "I feel like it's been experience and it's been success, it's been failure, it's been everything that created the opportunity for me to be able to be ready in those situations".
"I will just try to go out there like in Australia, trying to show her, okay, I'm here to win the match, as well".
"Obviously I'm 0 for two (this year) so hopefully I can win one this year".
Kerber's clash with Williams is a repeat of this year's Australian Open final.
Serena's win over Vesnina on Thursday guarantees she will remain the World No. 1 after Wimbledon for a 178th-straight week.
That means Venus still has a chance to leave Wimbledon with a trophy, just like her sister.
"She's playing well at the moment and I was moving good and I tried to go for it. That's why I'm so happy to reach my first Wimbledon final", Kerber said. Though Venus kept up scoreboard pressure on the German - even saving three break points in a 14-shot rally - she couldn't find a way to attack Kerber's serve and get back on even terms. I was always watching a lot of her matches, also on YouTube sometimes.
Williams looked exhausted after her efforts of the past 10 days, sighing often, shaking her head at times and breathing harder than usual after many points.