The Volunteers are the only top-4 seed in the South to lose in the conference tournaments.
N.C. Central will play in a "First Four" game Wednesday against Texas Southern.
A No. 16 seed has never beat a No. 1 seed in NCAA tournament history, so odds will remain low leading up to Friday's game, but don't doubt the 2017-18 Retrievers men's basketball team as they look to make history. Villanova was a No. 1 previous year and has consistently been a high seed under coach Jay Wright.
The Cavs are the top seed in the tournament and will play the University of Maryland, Baltimore County (UMBC) in the first round.
"I told our players that everyone can play if they're in there", Virginia coach Tony Bennett said.
Hard core March Madness participants already know when their office pool brackets are due - most likely by Thursday's games.
The Cavaliers have their traditional suffocating defense that ranks No. 1 in KenPom's adjusted defensive efficiency (84.4 points allowed per 100 possessions), while the methodical-tempo attack ranks 21st in offensive efficiency (116.5 points per 100 possessions).
The back-to-back NCAA Tournament invitations for Virginia Tech are the first time the Hokies have accomplished that feat since 1985 and 1986.
Things haven't gone smoothly for the Wildcats.
That commission's investigation, led by former Secretary of State Condoleezza Rice, started after the FBI charged assistant coaches, agents, employees of apparel companies and others in a federal bribery and fraud probe.
The Jayhawks (27-7) won a record 14th straight Big 12 regular-season championship and backed that up with the conference tournament title.
Coach John Calipari's latest crop of Kentucky freshmen just needed a little longer to figure things out. Gilgeous-Alexander was 10 of 16 from the field and added seven rebounds to help the Wildcats claim their 31st conference tournament title.
Duke, the second seed in the Midwest, will play Iona in Pittsburgh on Thursday.