He took 143 games for Leeds and Manchester United to reach that total, with Ozil beating him by two matches.
For Arsenal, Pierre-Emerick Aubameyang and Henrikh Mkhitaryan each contributed a goal and an assist after Shkodran Mustafi's header had given the Gunners an early lead in a clinical attacking display at the Emirates Stadium.
Wenger acknowledged that empty seats were a concern.
"I can't play every three days, and that is frustrating".
What made the achievement that much more special though is the fact the Germany global became the fastest player to reach 50 assists in the English top-flight, taking just 141 games to get there and, in doing so, breaking the record previously held by Eric Cantona (143 games). Arsenal ended a run of three successive Premier League defeats with a solid display yesterday.
Four of Mustafi's five Premier League goals have been assisted by Mesut Ozil (two from corners, two from free-kicks) - all four of the Ozil-assisted goals have been at the Emirates.
He added: "When you are in the hard moment and you have a run of results which go against you, you need to look at yourself and find the way out". It certainly showed in his last game against Watford, where he picked up a goal and an assist, and stuck a celebratory front flip for good measure. We dealt well with set-pieces, which is why they could not come back. You know what it is when you see your team playing - of course you want to play. And they're [rules] a bit ....not maybe stupid but something like that.
Watford play in the Premier League next Saturday with a trip to Liverpool (17:30 GMT).