The Colombian's header down was met at the far post by Vertonghen under pressure from Paul Dummett and the ball ricocheted down from the crossbar, with referee Martin Atkinson awarding the goal after being alerted that the ball had crossed the line. Newcastle walks away with the loss and an injury as DeAndre Yedlin left late with an apparent knee injury.
However, Spurs once again went in front as Dele Alli scored the third header of the match to put the north London club 2-1 in front in the 18th minute.
With no new faces joining the squad in the summer, Pochettino and his team are under pressure to get off to a good start to the season in order to justify stasis during the transfer window. I think the most important thing is that we are 25, 26, 28 players.
Spurs kick off their Premier League season with a visit to Newcastle on Saturday.
The Denmark worldwide delivered the resulting corner for defender Davinson Sanchez to attack.
Newcastle answered three minutes later, with Joselu meeting a cross from Matt Ritchie at the edge of the box and glancing a header past the helpless Hugo Lloris.
There were two fine chances at both ends during a frantic first 10 minutes of the second half; first Mo Diame hit the near post with a fierce left-footed volley from an angle, before the ball hit Alli's knee and looped into the grateful hands of Dubravka from Eriksen's cross.
The Magpies should have been level six minutes into the half when Joselu picked out Kenedy in acres of space, but the Brazilian's first touch let him down. Newcastle is a hard place to come.
According to Pochettino, Brexit has added another 30 per cent on to the cost of building their state-of-the-art new stadium, which will host it's first official game next month.
The gong could have also been awarded to Jan Vertonghen, but it was apt that England midfielder Alli scored the victor after a busy summer.