While Klopp can argue that the first-half red card to Sadio Mane changed the game, City were ruthless in dispatching their opposition.
City have won 20 of their 22 Premier League matches this season and drawn the other two.
The losses include a 6-0 mauling in 1995 and their overall record read 40 goals conceded to just 17 scored.
The midfield is the real worry against Manchester City, who have the likes of Kevin de Bruyne and David Silva ready to punish any missteps in the middle of the pitch. To top it, Mourinho has excluded Heinrilh Mkhitaryan from his plans as the Armenian looks set to depart Old Trafford as soon as this January.
"When I think about the game on Sunday, I can not forget the first we played against them", he added.
"He did a good job at [Borussia] Dortmund - I met him when he was there".
However, English football pundits believe that things could pan out differently on Sunday.
City also now hold a massive 15 point lead over their closest title challengers Manchester United in the race to be crowned champions.
RARELY can the gap between one team and the rest in the Premier League have felt so great. It will be a tough game, but I'm very much looking forward to it.
"The emergence of (Mohamed) Salah, that signing's been incredible".
"Alex Oxlade-Chamberlain is there, Adam Lallana is back, but obviously you are going to miss Coutinho".
England midfielder Lallana, 29, has started just two matches this term after spending most of the campaign on the sidelines due to a thigh injury.
He told the club's official website: "If we do something then it needs to be right decision, we don't have to replace him - what we have to do is step up".
Fans might plead that the Premier League is best and will forever be that way, but the one thing it did have over its competition was that it has always been competitive. I said, 'Wow, come on!'
Subplots abound. There is the issue of Liverpool's defence, capable of keeping clean sheets against the lesser lights but breached three times by Arsenal, four by Tottenham and five by City. He is constantly running behind you, and as right back or a centre back, you do not want to run that way the whole game. "That will be Liverpool's ploy".
While Coutinho's departure brought the curtain down on his role in Liverpool's attacking "Fab four", Klopp's three remaining big hitters will ensure the Reds pose a major threat to City's unbeaten record.