"We're anticipating still more snow through today, so we're asking motorists to stay home until the roads are cleared", said Missouri highway patrol Sgt Collin Stosberg.
Metro areas that are included in warnings are Kansas City, St. Louis, Indianapolis, Cincinnati, Washington D.C., Roanoke and Greensboro - these areas are most likely to see risky travel conditions and heavy snow and/or ice according to The Weather Channel.
The storm is headed east, where it's expected to blanket Washington and Baltimore, forecasters said. The center said about five to 10 inches of snow was expected in Virginia and three to five inches was expected to fall near Washington, D.C. Missouri received 10.8 inches on January 5-6, 2014, and 12.4 inches on March 23-24, 2013. IL state police said troopers along the MS river across from St Louis had responded to more than 100 crashes.
By late morning Saturday, officials had reported almost 11 inches of snow at Lambert International Airport in St. Louis, where most flights were canceled or delayed.
The National Weather Service has issued winter weather advisories for Missouri, as well as IL and Indiana.
A major winter storm is wreaking havoc on millions of Americans this weekend as it carves its way across the Midwest toward the Atlantic.
Sally Johnson, a meteorologist in St. Louis, says the storm has the potential to drop the most snow in five or six years.
The snow is due to taper off by 4:35 p.m. ET when the Kansas City Chiefs host the Indianapolis Colts in an National Football League playoff game, Brink said. The Missouri Department of Transportation (MoDoT) on Twitter warned residents not to travel in the storm if it isn't necessary. "More cancellations are likely on Saturday and Sunday", airport officials said.
The University of Missouri men's basketball game at the University of SC was also canceled Saturday because of weather-related travel issues, according to the team's Twitter account.
Along with Washington and Baltimore, Philadelphia is predicted to get 1 to 2 inches of snow, and there is a possibility of light accumulation in NY along the storm's northern edge.
"In much of swath from Missouri to southern OH, this will heavy and wet and a strain to shovel", AccuWeather meteorologist Bill Deger wrote in a blog post.
Much of the heart of Missouri is forecast to receive snow, ice or both throughout the night.
There is a small chance that the southern Appalachians get enough freezing rain and sleet to turn into an ice event Saturday into Sunday.
The Southeast has seen abundant precipitation in December and January, and the additional rain could put a strain on rivers already high.